Rainstorm with high winds rolls through Charleston area - News - The Charleston Gazette - West Vi
www.wvgazette.comCHARLESTON, W.Va. -- A rainstorm with high winds hit the Kanawha Valley this morning, knocking down some trees and contributing to several accidents.
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Between Microsoft's October launch of Windows 8 and yesterday's rollout of Microsoft Office 2013 and Office 365, there's no denying that it's been a decision-filled few months for PC users.
It seems safe to say that Windows 8 has not been received as enthusiastically as Microsoft might have liked, but Office is of course a whole different ballgame, as they say.
With numerous components and pricing plans, this cross-platform entry is surely Redmond's broadest-reaching office product to date.
Time will tell how well it does, but meanwhile there are plenty of alternatives for those who remain unconvinced. Here's a small sampling of what's available from the world of free and open source software.
Certainly the leading office productivity suite on the open source side is LibreOffice. In the two or so years since it was forked from OpenOffice, it's become the suite most commonly included by the top Linux distributions. With six feature-rich applications for word processing, spreadsheets, presentations, and more, the software had already been downloaded some 20 million times by last fall. It's available as a free download for Windows, Mac, and Linux.
Then, too, there's Apache OpenOffice, now under the purview of the Apache Software Foundation. OpenOffice is what LibreOffice is based on, so the two share many similarities; development work seems to be progressing more quickly on the latter, however. Not to be confused with the German variation now known as White Label Office, this suite is available as a free download at the project site.
Stepping a bit closer to Microsoft's new suite in terms of cross-platform compatibility is Calligra Suite, a graphics and office suite created by the KDE project from KOffice in 2010. With versions for desktop PCs, tablets, and smartphones, this package includes eight components spanning word processing, spreadsheets, presentations, databases, vector graphics, and more. It can be downloaded?for free for Linux, FreeBSD, OS X, and Windows.
OxygenOffice Professional, meanwhile, is an enhanced version of OpenOffice that comes with extra goodies including templates, clip art, samples, fonts, and Visual Basic for Applications (VBA) support. Now in version 3.2.1, this free software can be downloaded for 32-bit Windows as well as 32- and 64-bit Linux.
Finally, there's Feng Office Community Edition, a free and open source online project management and collaboration tool formerly known as OpenGoo that offers task management, document management, project management, time tracking, knowledge management, and more. Users of the software can create and edit text documents and presentations online; they can also upload, organise, and share files. The free software can be downloaded online; paid professional versions are also available starting at $59 per month.
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Men with erection problems now have an extra reason to see their doctor: even relatively minor erectile difficulties could signal 'silent' heart disease and may indicate an increased risk of dying early from any cause, a major new study shows.
An Australian study ? the world's largest to investigate the link between erectile dysfunction and heart disease ? has found that men with erectile dysfunction have a higher risk of hospital admission for heart disease, even if they have no history of heart problems. They are also at greater risk of premature death from any cause.
The research, from the Sax Institute's 45 and Up Study and published in international journal PLOS Medicine today, is the first to show a direct link between how severe a man's erection problem is and his risk of dying early or being treated in hospital for heart disease.
"The risks of future heart disease and premature death increased steadily with severity of erectile dysfunction, both in men with and without a history of cardiovascular disease," lead author and 45 and Up Study Scientific Director Professor Emily Banks said.
"Rather than causing heart disease, erectile dysfunction is more likely to be a symptom or signal of underlying 'silent' heart disease and could in future become a useful marker to help doctors predict the risk of a cardiovascular problem. This is a sensitive topic but men shouldn't suffer in silence; there are many effective treatments, both for erectile dysfunction and for cardiovascular disease."
Erection problems are very common: around one in five men aged 40 and over report moderate or severe erectile dysfunction.
While previous studies have shown that men with severe erectile dysfunction are more likely than men with no erectile difficulties to have cardiovascular events such as heart disease or stroke, this study (funded by the Heart Foundation and the NSW Office for Health and Medical Research) is the first to review gradients of erectile dysfunction from none, to mild, moderate and severe forms.
Heart Foundation Cardiovascular Health Director Dr Rob Grenfell said the results were nationally significant and demonstrated why governments should invest in large health studies such as the 45 and Up Study.
"These results tell us that every man who is suffering from any degree of erectile dysfunction should be seeking medical assistance as early as possible and also insisting on a heart health check by their GP at the same time," Dr Grenfell said.
The researchers, from the Sax Institute, Australian National University, The University of Sydney, Victor Chang Cardiac Research Institute and The George Institute for Global Health examined hospital and death records for 95,000 men from the 45 and Up Study ? the largest ongoing study of healthy ageing in the Southern Hemisphere, with more than 250,000 people taking part.
The men gave information about health and lifestyle factors and were followed for a two to three-year period, recording 7855 hospital admissions related to cardiovascular disease and 2304 deaths.
"The large number of men in the study meant we could also look at the risks in relation to different types of cardiovascular disease," Professor Banks said. "We found men with erectile dysfunction were at higher risk of heart attack, heart failure, peripheral vascular disease and heart conduction problems."
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Sax Institute: http://www.saxinstitute.org.au
Thanks to Sax Institute for this article.
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Jan. 30, 2013 ? Wear is a fact of life. As surfaces rub against one another, they break down and lose their original shape. With less material to start with and functionality that often depends critically on shape and surface structure, wear affects nanoscale objects more strongly than it does their macroscale counterparts.
Worse, the mechanisms behind wear processes are better understood for things like car engines than nanotech devices. But now, researchers at the University of Pennsylvania's School of Engineering and Applied Science have experimentally demonstrated one of the mechanisms behind wear at the smallest scale: the transfer of material, atom by atom, from one surface to another.
The research was conducted by Tevis Jacobs, a doctoral student in the Department of Materials Science and Engineering, and Robert Carpick, department chair of Mechanical Engineering and Applied Mechanics.
Their research was published in the journal Nature Nanotechnology.
On the nanoscale, wear is mainly understood through two processes, fracture and plastic deformation. Fracture is where large pieces of a surface break off at once, like when the point of a pencil snaps off in the middle of a sentence. Plastic deformation is what happens when the surface changes shape or compresses without breaking, like when the edge of knife gets dull or bent.
These mechanisms typically affect thousands or millions of atoms at a time, whereas nanoscale wear often proceeds through a much more gradual process. Determining the mechanisms behind this more gradual process is key to improving such devices.
"At the nanoscale, wear is a very significant problem," Jacobs says. "Nanotechnology is developing smaller and smaller parts for very tiny machines. Their contact interfaces wear out very quickly, sometimes surviving for hundreds of cycles when they need to survive for trillions or more."
One wear mechanism that had been hypothesized for the nanoscale is a process known as atomic attrition. There, atoms from one surface are transferred to the other surface via a series of individual bond-forming and bond-breaking chemical reactions. Other researchers have attempted to test this process by putting two surfaces in contact and sliding one against the other.
Those previous investigations involved Atomic Force Microscopes. Using an AFM involves dragging a very sharp tip mounted on a flexible cantilever over a surface while a laser aimed at the cantilever precisely measures how much the tip moves. By using the tip as one of the surfaces in a wear experiment, researchers can precisely control the sliding distance, sliding speed and load in the contact. But the AFM doesn't visualize the experiment at all; the volume of atoms lost from the tip can only be inferred or examined after the fact, and the competing wear mechanisms, fracture and plastic deformation can't be ruled out.
The Penn team's breakthrough was to conduct AFM-style wear experiments inside of a transmission electron microscope, or TEM, which passes a beam of electrons through a sample (in this case, the nanoscale tip) to generate an image of the sample, magnified more than 100,000 times.
By modifying a commercial mechanical testing instrument that works inside a TEM, the researchers were able to slide a flat diamond surface against the silicon tip of an AFM probe. By putting the probe-cantilever assembly inside the TEM and running the wear experiment there, they were able to simultaneously measure the distance the tip slid, the force with which it contacted the diamond and the volume of atoms removed in each sliding interval.
"We can watch the whole process live to see what happens while the surfaces are in contact," Jacobs said. "Then, after each pass, we use the TEM like a camera and take an even higher magnification picture of the tip. We can trace its outline and see how much volume has been lost, down to as small as 25 square nanometers, or about 1250 atoms.
"We are measuring changes in volume that are one thousand times smaller than can be seen using other techniques for wear detection."
While this new microscopy method can't image individual atoms moving from the silicon tip to the diamond punch, it enabled the researchers to see the atomic structure of the wearing tip well enough to rule out fracture and plastic deformation as the mechanism behind the tip's wear. Proving that the silicon atoms from the tip were bonding to the diamond and then staying behind involved combining the visual and force data into a mathematical test.
"If atomic attrition is what's happening," Carpick said, "then the rate at which those bonds are formed and the dependence on contact stress -- the force per unit area -- is well-established science. That means we can apply chemical kinetics, or reaction rate theory, to the wear process."
Now that they could measure the volume of atoms removed, the distance the tip slid and the force of the contact for each experimental test, the researchers could calculate the rate at which the silicon-diamond bonds form under different conditions and compare that to predictions based on reaction rate theory, a theory that is routinely used in chemistry.
"The more force the atoms are under, the more likely they are to form a bond with an atom on the opposing surface, so the wear rate should accelerate exponentially with additional stress," Jacobs said. "Seeing that in the experimental data was a smoking gun. The trend in the data implies that we can predict the rate of wear of the tip, knowing only the stress levels in the contact, as long as this wear mechanism is dominant."
For now, those predictions can only be made about the wear of silicon on diamond in a vacuum, though the selection of those two materials was not accidental. They are common in nanoscale devices and tools for nanomanufacturing.
The math behind the atomic attrition mechanism could eventually be applied in a fundamental way.
"The goal of this avenue of research is to get to the point where you tell me the materials in contact, and you tell me the period they are in contact and the stresses applied and I will be able to tell you the rate at which atoms will be removed," Jacobs said.
"With a fundamental understanding of wear, you can cleverly design surfaces and choose materials to make longer lasting devices," Carpick said.
This fundamental, predicative understanding of wear could vastly improve nanomechanical design, increasing functionality and decreasing costs.
The research was supported by the National Science Foundation's Nanomanufacturing Program and Penn's NanoBio Interface Center.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/physics/~3/VDlPqGsjSXE/130130121643.htm
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Jan. 28, 2013 ? A team of materials scientists at Harvard University and the University of Exeter, UK, have invented a new fiber that changes color when stretched. Inspired by nature, the researchers identified and replicated the unique structural elements that create the bright iridescent blue color of a tropical plant's fruit.
The multilayered fiber, described January 28 in the journal Advanced Materials, could lend itself to the creation of smart fabrics that visibly react to heat or pressure.
"Our new fiber is based on a structure we found in nature, and through clever engineering we've taken its capabilities a step further," says lead author Mathias Kolle, a postdoctoral fellow at the Harvard School of Engineering and Applied Sciences (SEAS). "The plant, of course, cannot change color. By combining its structure with an elastic material, however, we've created an artificial version that passes through a full rainbow of colors as it's stretched."
Since the evolution of the first eye on Earth more than 500 million years ago, the success of many organisms has relied upon the way they interact with light and color, making them useful models for the creation of new materials. For seeds and fruit in particular, bright color is thought to have evolved to attract the agents of seed dispersal, especially birds.
The fruit of the South American tropical plant, Margaritaria nobilis, commonly called "bastard hogberry," is an intriguing example of this adaptation. The ultra-bright blue fruit, which is low in nutritious content, mimics a more fleshy and nutritious competitor. Deceived birds eat the fruit and ultimately release its seeds over a wide geographic area.
"The fruit of this bastard hogberry plant was scientifically delightful to pick," says principal investigator Peter Vukusic, Associate Professor in Natural Photonics at the University of Exeter. "The light-manipulating architecture its surface layer presents, which has evolved to serve a specific biological function, has inspired an extremely useful and interesting technological design."
Vukusic and his collaborators at Harvard studied the structural origin of the seed's vibrant color. They discovered that the upper cells in the seed's skin contain a curved, repeating pattern, which creates color through the interference of light waves. (A similar mechanism is responsible for the bright colors of soap bubbles.) The team's analysis revealed that multiple layers of cells in the seed coat are each made up of a cylindrically layered architecture with high regularity on the nano- scale.
The team replicated the key structural elements of the fruit to create flexible, stretchable and color-changing photonic fibers using an innovative roll-up mechanism perfected in the Harvard laboratories.
"For our artificial structure, we cut down the complexity of the fruit to just its key elements," explains Kolle. "We use very thin fibers and wrap a polymer bilayer around them. That gives us the refractive index contrast, the right number of layers, and the curved, cylindrical cross-section that we need to produce these vivid colors."
The researchers say that the process could be scaled up and developed to suit industrial production.
"Our fiber-rolling technique allows the use of a wide range of materials, especially elastic ones, with the color-tuning range exceeding by an order of magnitude anything that has been reported for thermally drawn fibers," says coauthor Joanna Aizenberg, Amy Smith Berylson Professor of Materials Science at Harvard SEAS, and Kolle's adviser. Aizenberg is also Director of the Kavli Institute for Bionano Science and Technology at Harvard and a Core Faculty Member at the Wyss Institute for Biologically Inspired Engineering at Harvard.
The fibers' superior mechanical properties, combined with their demonstrated color brilliance and tunability, make them very versatile. For instance, the fibers can be wound to coat complex shapes. Because the fibers change color under strain, the technology could lend itself to smart sports textiles that change color in areas of muscle tension, or that sense when an object is placed under strain as a result of heat.
Additional coauthors included Alfred Lethbridge at the University of Exeter, Moritz Kreysing at Ludwig Maximilians University (Germany), and Jeremy B. Baumberg, Professor of Nanophotonics at the University of Cambridge (UK).
This research was supported by the U.S. Air Force Office of Scientific Research Multidisciplinary University Research Initiative, by the UK Engineering and Physical Sciences Research Council, and through a postdoctoral research fellowship from the Alexander von Humboldt Foundation. The researchers also benefited from facilities at the Harvard Center for Nanoscale Systems, which is part of the National Nanotechnology Infrastructure Network supported by the U.S. National Science Foundation. The Wyss Institute for Biologically Inspired Engineering at Harvard also contributed to this research.
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Monday, January 28th, 2013. 8 views.
Sometimes when you first step onto the road of personal development, it can all be a little overwhelming. There are also a lot of different improvement avenues to chose from. Personal development can range from improving your diet to enhancing your social skills. Self improvement can be achieved in many different ways. The main goal of personal development is to improve the way that you feel about yourself, but it is quite probable that others around you will notice the changes too.
Set realistic, attainable goals for yourself to ensure that you are envisioning an achievable, healthy lifestyle. By taking some time our for yourself to focus on both strengths and weaknesses, you will notice overall self-improvement.
Take the time to research the lives of successful people. Studying the processes used by others will help you better develop your own self improvement strategies. Knowing that other people have succeeded at the same goal will make it seem more attainable to you.
Be on the lookout for new ways to challenge yourself. Discovering new challenges is a great way to open yourself up to new possibilities. You can learn more and acquire new skills. You may even start a new model by doing something that has never been done before. Do something new and unique, instead of copying others.
TIP! Seeking advice from a counselor, or paster can be a wonderful source to help guide you. They have a great deal of experience in dealing with personal thoughts and are even licensed to do so.
When you are actively trying to improve yourself, failing to do well at something can hurt your self-esteem more than it otherwise would. Actually, failure is really a learning experience. Failure is a way of learning your weaknesses and your strengths. Looking at it this way, failure is a source of pride, because you?ve unlocked another piece of the puzzle when it comes to your development.
Get organized. You will feel accomplished and your mind will feel clearer. This also helps relieve you from stress caused by disorganization. When everything is in a proper place, life is a bit more calm.
Take the time to change the focus of your conversation from your own accomplishments and awards to the achievements of those around you. You?ll be able to find out about the wonderful things the people you know have accomplished, bringing about a new-found respect and admiration for them.
Find texts that help you. This could be a holy text for some people. For others, it could just a book of inspirational sayings. Sometimes having a physical representation of comfort can help you better manage your day-to-day life.
TIP! Make the most of your work time to accomplish more. One trick to doing this, is to take more breaks.
Improving your life is closely tied to willpower, and a lot can be said for the karma you develop along the way. This means that you are wise to only wish good things upon others. If you endeavor to be positive about all things, then that positivity will come back to you.
Learn to deal with stressful situations without reacting in an emotional way. Learning ways to maintain your composure when stressed will help boost your self-esteem, and help you triumph under any circumstance. Breathing deeply can be a powerful way to reduce stress and stay in the moment.
The worst way to deal with a situation is by overreacting. This will cause you unneeded and unnecessary stress. It?s best to train yourself to cope with your daily stress, and it begins with analyzing every situation where you tend to feel strained. If you screw up, you can probably fix it, or at least find a way to minimize the damage. Rather than dwelling on what you?ve lost, look at the things you still have.
Leadership is about exercising authority, but good leaders are humble, too. When delivering criticisms, remember that you should be firm, yet friendly. You will not go far if you forget your own willingness to serve. A successful leader is one who demonstrates integrity and virtue as an example to others.
TIP! Writing out your goals will help you develop your own plan for personal growth. Record the behaviors and character traits you wish to have; for example, you might list patience or gratitude.
It is impossible for you to properly care for the ones you love, unless you take care of yourself first. It doesn?t matter if you are succeeding or failing in your path. You should always find time to rest your body so that you can renew yourself.
Strive to improve daily so that each one is more perfect than the previous. Set a goal of continuous improvement through steady efforts. Try your hardest to achieve something different today than what you achieved yesterday.
Make a list of your priorities, and plan your life around these elements. When it comes to focusing your feelings and emotions, strive to apply them to the important aspects of your life that build happiness, and do not waste them on the negative aspects that weigh you down and prevent inner peace.
Your core principles are important, and your actions should reflect them. Everyone has basic principles by which they define themselves. Having a good foundation based on your core principles will benefit your sense of self esteem. Better yet, this practice encourages consistency, which is an excellent character trait to maintain.
TIP! Live your life with wisdom and humility. There are certain things in your life that you just can?t change.
Anytime and anywhere, be ready for when your ideas strike. Make sure you have a notepad on you at all times. Scribble detailed notes when something comes to you, and then carry them out whenever your creativity is piqued.
It is essential to have a clearly outlined goal, when working toward improving self improvement. Make sure to come up with a target goal for yourself. If you are clear about your goals, it will be easier to measure how well you have achieved them.
Our goal in this article was to help you to accomplish a start on your self improvement plans. However, there are many other ways in which you may further improve your life. No matter your age, you can always work on becoming a better person for both yourself and others.
Maintaining a positive attitude will get you through a lot of tough times while allowing you to grow and mature. If you do not have a good attitude you will never get as far as you could have. Maintain a positive approach to life in order to reach your goals.
TIP! One new trait that is being researched and is very important to develop is known as sexual capitol. It does not refer to using sexuality in a manipulative way.
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Source: http://rodt-st.com/using-self-improvement-to-improve-your-mind-body-and-mood/
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By Leah Schnurr
NEW YORK (Reuters) - Home prices rose in November to rack up their best yearly gain since the housing crisis began, a further sign that the sector is on the mend.
But data on consumer confidence on Tuesday was less encouraging, with moods falling to their lowest level in more than a year as Americans became more pessimistic about the economic outlook and their financial prospects in the wake of higher taxes for many.
The S&P/Case Shiller composite index of 20 metropolitan areas gained 0.6 percent in November on a seasonally adjusted basis, in line with economists' forecasts.
Prices in the 20 cities rose 5.5 percent year over year, making for the strongest yearly price increase since August 2006 when prices were on their way down.
The housing market became a bright spot for the economy last year as prices rose and inventory tightened. The sector is expected to contribute to economic growth in 2013.
"What we're seeing is really a gradual improvement in the overall economy," said Anthony Chan, chief economist for Chase Private Client in New York.
Rising home prices and recent gains in the stock market should blunt the impact of tax increases for consumers and spending should improve by the second half of the year, said Chan.
Homebuyers also have been enticed by historically low interest rates. The Federal Reserve's latest stimulus efforts are helping to keep rates low, as the central bank buys assets including mortgage-backed securities.
The Fed meets on Tuesday for the first session of a two-day meeting, with a statement due on Wednesday.
It was the 10th month in a row that prices have increased, the longest string of gains since before 2006. Last year's rise in prices beat a nine-month consecutive run in 2009 and 2010, when the market was boosted by a homebuyer tax credit.
A number of challenges remain for the housing market, including tight access to mortgages and on-going foreclosures.
Highlighting the hurdles on the path to recovery, separate government data showed the homeownership rate slipped to 65.4 percent in the fourth quarter from 65.5 percent.
Consumer attitudes dropped more than expected to 58.6 in January, data from The Conference Board showed. It was the lowest level since November 2011.
At the start of the year, U.S. politicians came to an agreement that averted the so-called fiscal cliff of spending cuts and tax increases that had been set to come into effect.
But the deal did raise taxes for many Americans, while a payroll tax holiday came to an end. Lawmakers still face a number of budget decisions.
"Consumers are probably pretty unhappy to notice that their payroll taxes have gone up," said David Sloan, economist at 4Cast Ltd in New York.
U.S. stocks pared slight gains immediately after the report was released, but Wall Street was modestly higher by midday.
The Conference Board's consumer expectations index tumbled to its lowest level since October 2011 at 59.5, while the present situation measure slipped to 57.3.
Consumers' views on the labor market were also weaker, with the "jobs hard to get" index rising for the first time since September.
Economists said the pain should be short lived and that confidence was likely to perk back up as long as Washington can come to an agreement on the budget issues yet to be resolved.
"This might bounce back pretty quickly as people get used to a smaller paycheck. Right now, it's a sticker shock," said Craig Dismuke, chief economic strategist at Vining Sparks in Memphis, Tennessee.
Home prices on a non-adjusted basis slipped 0.1 percent. The non-adjusted numbers showed prices fell in about half of the cities covered by the survey, with the winter months typically a weak period for housing, the survey said.
Phoenix, which saw its housing market rebound sharply last year, led with the biggest yearly gain at 22.8 percent. New York was the only city to fall, down 1.2 percent from the previous year.
(Additional reporting by Richard Leong and Chris Reese; Editing by Chizu Nomiyama)
Source: http://finance.yahoo.com/news/home-prices-continue-climb-november-140149324.html
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Elizabeth Forward sixth-grader Alexis Korenosky presents a check to Don Furko of the Pancreatic Cancer Action Network while gifted support teacher Lois Leggett, left, and Janice Korenosky look on. Cindy Shegan Keeley | Daily News
Published: Sunday, January 27, 2013, 9:00?p.m.
Updated 17 hours ago
When Alexis Korenosky had to do a project for her Gifted And Talented Education class to raise money for an organization, the decision was easy.
?I was thinking of my Pap and I wanted to do something to make a difference and that was important to me,? the Elizabeth Forward sixth-grader said. ?My Pap died of pancreatic cancer so I wanted to raise money for that.?
She first thought of having a walk-a-thon but her gym teacher suggested a dance-a-thon, which is what she did but with a twist ? it was a Wii dance-a-thon.
The Nov. 12 ?Dance for Pancreatic Cancer? also had a Chinese auction and bake sale.
?It was pretty hard to put together,? she said of the project. ?I was worried at first that no one would come, but we had so many people. I couldn?t believe it.?
Her hard work paid off and last week she presented a check for $609 to Don Furko, affiliate coordinator for the Pittsburgh Affiliate of the Pancreatic Cancer Action Network.
Middle school principal Mike Routh was impressed with Alexis? project.
?I really never saw kids have such a great time. Some kids you wouldn?t think would take part in something like that did. It was an awesome event and we need to do more things like that,? Routh said.
Gifted support teacher Lois Leggett said she encourages the students to devise a business plan for a project. ?This really meant something to Alexis and it showed in what all she did.?
Janice Korenosky said she is proud of her daughter.
?She was very close to my dad, who died of pancreatic cancer three years ago in February,? Janice Korenosky said. ?This was very important to her and she really did a lot of work. I think this really helped our family because we were able to do something to raise more awareness of pancreatic cancer.?
Janice Korenosky said her father was never sick. He was diagnosed with diabetes first then he became jaundiced and that?s when doctors discovered the cancer. ?He lived for a year after he was diagnosed. He was 71 when he died,? she said.
Furko said his father also died of pancreatic cancer ? 55 days after being diagnosed and not long after being diagnosed with diabetes.
?My dad was always about 205 pounds but he experienced severe weight loss that could not be explained. The cancer wasn?t diagnosed until he experienced pain,? Furko said.
Citing how deadly pancreatic cancer is, Furko said the survival rate five years after diagnosis is 6 percent, the lowest of all cancers. The first-year survival rate is 25 percent.
This year, he said, 44,000 people will be diagnosed with pancreatic cancer and 37,000 will die.
?The number that will die of this cancer this year is about how many people will fit in PNC Park,? Furko said. ?We hope to double the survival rate by 2020.?
Furko said there appears to be a link between being diagnosed with diabetes after age 40 and pancreatic cancer. ?We don?t know what comes first, the cancer or diabetes. My dad?s pancreas was malfunctioning and that?s how his diabetes was diagnosed. Better testing is needed for pancreatic cancer. Of the 10 major cancers, this is the only one with no preemptive testing.?
Some symptoms of this cancer include back pain, abdominal pain, and reflux. While those are things the person can experience, there are some signs others may see that could indicate a problem such as jaundice or drastic, unexplained weight loss.?
Just as Alexis did something in her Pap?s memory, Furko promised in his father?s eulogy that he would do something to spread the word about pancreatic cancer. That something occurred in November 2011 when he was in Harrisburg and saw a large group with purple T-shirts ? the color symbolic for this type of cancer. That?s when he got involved with the Pittsburgh group.
Looking ahead, Alexis said she may do more to raise awareness of pancreatic cancer. ?I might do something different next year to raise money for this because it?s a good cause.?
The Pittsburgh Affiliate of the Pancreatic Cancer Action Network meets monthly at Gilda?s Club. The next meeting is Feb. 14 at 6:30 p.m. Information is available online at pancan.org/pgh.
Carol Waterloo Frazier is an editor for Trib Total Media. She can be reached at 412-664-9161, ext. 1916, or cfrazier@tribweb.com.
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Ben Affleck arrives at the 24th Annual Producers Guild Awards at the Beverly Hilton Hotel on Saturday Jan. 26, 2013, in Beverly Hills, Calif. (Photo by John Shearer/Invision/AP Images)
Ben Affleck arrives at the 24th Annual Producers Guild Awards at the Beverly Hilton Hotel on Saturday Jan. 26, 2013, in Beverly Hills, Calif. (Photo by John Shearer/Invision/AP Images)
Amanda Seyfried arrives at the 24th Annual Producers Guild Awards at the Beverly Hilton Hotel on Saturday Jan. 26, 2013, in Beverly Hills, Calif. (Photo by John Shearer/Invision/AP Images)
Nicole Kidman, left, and Naomi Watts arrive at the 24th Annual Producers Guild Awards at the Beverly Hilton Hotel on Saturday Jan. 26, 2013, in Beverly Hills, Calif. (Photo by John Shearer/Invision/AP Images)
Anne Hathaway arrives at the 24th Annual Producers Guild Awards at the Beverly Hilton Hotel on Saturday Jan. 26, 2013, in Beverly Hills, Calif. (Photo by John Shearer/Invision/AP Images)
Nicole Kidman, left, and Naomi Watts arrive at the 24th Annual Producers Guild Awards at the Beverly Hilton Hotel on Saturday Jan. 26, 2013, in Beverly Hills, Calif. (Photo by John Shearer/Invision/AP Images)
LOS ANGELES (AP) ? "Argo" continues to shake up the Oscar race by taking the top honor at the Producers Guild Awards on Saturday.
Ben Affleck, coming off winning Golden Globe Awards for best motion picture drama and director for the real-life drama, received the award handed out at the Beverly Hilton Hotel.
"I'd be remiss if I didn't mention that I'm still working as an actor," he said in his acceptance speech.
Affleck also stars in "Argo" as the CIA operative who orchestrated a daring rescue of six American embassy employees during the 1979 Iranian hostage crisis. George Clooney and Grant Heslov share the producer award with Affleck as "Argo" beat out the Civil War saga "Lincoln," which has a leading 12 Academy Awards nominations.
Other nominees in the PGA movie category were "Les Miserables," ''Zero Dark Thirty," ''Beasts of the Southern Wild," ''Django Unchained," ''Life of Pi," ''Moonrise Kingdom," ''Silver Linings Playbook," and Skyfall."
Along with honors from other Hollywood professional groups such as actors, directors and writers guilds, the producer prizes have become part of the preseason sorting out contenders for Academy Awards.
The big winner often goes on to claim the best-picture honor at the Oscars on Feb. 24.
Disney's "Wreck-It Ralph" won the guild's animation category, beating "Brave," ''Frankenweenie," ''ParaNorman" and "Rise of the Guardians."
"Searching for Sugar Man" took the documentary prize, beating "A People Uncounted," ''The Gatekeepers," ''The Island President," and "The Other Dream Team."
Showtime's "Homeland" won the producer's award for television drama series, which beat out "Breaking Bad," ''Downton Abbey," ''Game of Thrones," and "Mad Men."
The ABC sitcom "Modern Family" took the prize for best comedy series for the third straight year, beating "30 Rock," ''The Big Bang Theory," ''Curb Your Enthusiasm," and "Louie."
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Researchers at Moffitt Cancer Center and colleagues at Wayne State University School of Medicine investigated the acidity in solid tumors to determine if pH levels play a role in cancer cell invasion in surrounding tissues. They found that an acidic microenvironment can drive cancer cells to spread and propose that neutralizing pH would inhibit further invasion, providing a therapeutic opportunity to slow the progression of cancers.
Their study appeared in the Jan. 3 online release of Cancer Research, a publication of the American Association for Cancer Research.
According to the study's corresponding author, Robert J. Gillies, Ph.D., chair of the Department of Cancer Imaging & Metabolism at Moffitt, acidity in solid tumors is the result of an increased fermentative metabolism combined with poor delivery of blood to tissues.
In this study, tumor invasion and pH were monitored in immunodeficient laboratory mice hosting a variety of tumors. "We monitored the test animals over time using microscopy and found that the highest regions of tumor invasion corresponded to areas with the lowest pH," Gillies explained. "Tumor invasion did not occur in regions with normal or near normal pH levels. Furthermore, when we neutralized the acidity with oral sodium bicarbonate, the invasion was halted."
Researchers proposed that the acidic pH of the tumor microenvironment represents a "niche engineering" strategy on the part of tumor cells, promoting invasion and growth of malignant tumors into surrounding tissue. Niche engineering is a concept in ecology describes how plants and animals alter their environment to in ways that promote their own growth and survival over their competitors. "We have long regarded cancers cells as an invading species," said study co-author Robert Gatenby, M.D., chair of the Diagnostic Imaging Services and Integrated Mathematical Oncology departments at Moffitt.
A key to this process of adaptation and invasion is increased glucose metabolism in the tumor. "The vast majority of malignant tumors metabolize glucose at high rates," Gillies said. "We have proposed that there is a direct, causative link between increased glucose metabolism and the ability of cancer cells to invade and metastasize."
According to the research, elevated glucose metabolism is the cause of increased acidity in the tumor microenvironment. Most tumors develop an abnormal vascular network that tends to be poorly organized and leaky, disrupting blood flow and hampering the delivery of oxygen.
"This poorly organized vascular system has a two-fold effect on tumor acidity," explained Gatenby. "First, it subjects tumor regions to poor perfusion, which restricts oxygen and increases the rate of glucose fermentation. Second, the poor perfusion hampers the ability to eliminate the resulting acids, resulting in very low pH in surrounding tissues."
As tumor cells adapt to increasing acidity, niche engineering through normal cell death and new blood vessel formation occurs in the tumor and the immune response is suppressed.
"Tumor cells perform niche engineering by creating an acidic environment that is not toxic to the malignant cells but, through its negative effects on normal cells and tissues, promotes local invasion of malignant cells," Gatenby said.
The researchers suggested that targeting this activity with buffers and other mechanisms aimed at increasing pH levels will likely provide a valuable alternative to traditional therapies focused entirely on killing tumor cells.
###
H. Lee Moffitt Cancer Center & Research Institute: http://www.moffitt.usf.edu
Thanks to H. Lee Moffitt Cancer Center & Research Institute for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Source: http://www.labspaces.net/126473/Tumor_cells_engineer_acidity_to_drive_cell_invasion
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6 hrs.
We've?talked before?about using a longer passcode on your iPhone instead of a 4-digit pin, but as the tech blog Digital Inspiration points out, adding in accented characters adds yet another level of security.
The idea is that most people aren't going to bother dealing with accented characters (if you hold down on a letter, the available accented characters show up) when they're trying to guess your password. To use these, you first have to turn on the alphanumeric passcode. Just head into Settings > General > Passcode Lock, and turn off Simple Passcode. You'll be asked to enter in a new password, so throw in a few accented characters. It might make it a bit of a pain to enter in your passcode, but at least it's more secure.
[via Digital Inspiration]
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What's most galling about this tragedy is that it could have been avoided if not for a legal technicality.
A man named Ernest Valenzuela had confessed the crime to his attorney?before later dying in a prison fight. The attorney's testimony could have vindicated Macumber. Instead, a judge protected the attorney-client privilege of the dead man and let the innocent man go to jail.
When Macumber came to trial in 1975, Valenzuela's former public defender Thomas O'Toole wrote to the trial judge asking to testify about his now-dead client's confession.
However, Judge Charles Hardy wouldn't allow the confession to be heard.
"Let the record show the Court has ruled that the proffered evidence isn't admissible," Hardy said in his ruling, according to the book. "First because the communications to Mr. O'Toole and Mr. Petica [another of Valenzuela's defense attorneys] were privileged because of the attorney-client relationship. There's no waiver of the privilege."
After Macumber was sentenced to life behind bars, his defense team appealed the case all the way to the Arizona Supreme Court.
The state Supreme Court ultimately gave him a retrial because of issues with ballistics evidence.
But in its ruling granting him a retrial, the Arizona Supreme Court ruled the trial court could still "assert" the attorney-client privilege on behalf of the dead man and exclude his testimony if it wanted to.
But yet again, the court ruled against Macumber, with Judge Robert Corcoran saying attorney-client privilege prevented the testimony. Macumber was convicted a second time.
After reading the book, we were shocked that a dead man's rights would supersede those of a living man who was fighting for his life.But according to legal ethics expert Andrew Perlman, who teaches procedure and professional responsibility at Suffolk University Law School, the court made the right decision with respect to the law.
"It is not shocking to me that a court would uphold the privilege here, even though doing so might have produced an unjust outcome in this particular case," Perlman said in an email to Business Insider. "The problem is that if courts reject the privilege any time it might be perceived as necessary to uncover the truth, clients would become quite concerned about sharing any information with their lawyers. Although I believe that there should be an exception to the duty of confidentiality to permit lawyers to disclose information necessary to prevent the wrongful execution or incarceration of an innocent person, I am not convinced that such a disclosure should have the effect of waiving the attorney-client privilege."
Macumber was?released from prison in November 2012 after the Arizona Justice Project got involved and filed motions that successfully questioned the judges' decisions to not allow Valenzuela's testimony, The Republic reported at the time.
DON'T MISS: Can James Holmes' Psychiatrist Be Held Responsible For 'The Dark Knight' Massacre? >
Source: http://www.businessinsider.com/bill-macumber-case-legal-technicalities-2013-1
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CAIRO (Reuters) - Egyptian President Mohamed Mursi announced on Sunday he was imposing a state of emergency for 30 days in three cities along the Suez Canal that have been the scene of the worst violence that flared at the weekend, killing more than 45 people.
Mursi made the announcement in a televised address in which he said a curfew would also be introduced in Port Said, Ismailia and Suez starting Monday from 9 p.m. (2 p.m. ET) to 6 a.m. (11 p.m. ET). He also called for dialogue with top politicians.
(Reporting by Yasmine Saleh; Writing by Edmund Blair; Editing by Jon Hemming)
Source: http://news.yahoo.com/egypt-president-declares-state-emergency-three-cities-201337482.html
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Baylor's Brittney Griner (42) blocks the shot of Oklahoma's Joanna McFarland (53) during the second half of an NCAA college basketball game Saturday, Jan. 26, 2013, in Waco Texas. It was Griners' 665th career blocked shot, surpassing the NCAA women's record set by Louella Tomlinson for St. Mary's in California from 2007-11. Baylor won 82-65. (AP Photo/LM Otero)
Baylor's Brittney Griner (42) blocks the shot of Oklahoma's Joanna McFarland (53) during the second half of an NCAA college basketball game Saturday, Jan. 26, 2013, in Waco Texas. It was Griners' 665th career blocked shot, surpassing the NCAA women's record set by Louella Tomlinson for St. Mary's in California from 2007-11. Baylor won 82-65. (AP Photo/LM Otero)
Baylor's Brittney Griner (42) shoots against Oklahoma's Nicole Griffin (4) during the first half of an NCAA college basketball game Saturday, Jan. 26, 2013, in Waco Texas. (AP Photo/LM Otero)
Baylor's Brooklyn Pope (32) shoots against Oklahoma's Aaryn Ellenberg (3) during the first half of an NCAA college basketball game Saturday, Jan. 26, 2013, in Waco Texas. (AP Photo/LM Otero)
Baylor's Brittney Griner (42) shoots against Oklahoma's Nicole Griffin (4) during the first half of an NCAA college basketball game Saturday, Jan. 26, 2012, in Waco Texas. (AP Photo/LM Otero)
Baylor's Odyssey Sims (0) drives the lane against Oklahoma's Morgan Hook, left, during the first half of an NCAAcollege basketball game Saturday, Jan. 26, 2013,. in Waco Texas. (AP Photo/LM Otero)
WACO, Texas (AP) ? Brittney Griner now has the record she has always wanted.
How about a block party for the two-time All-American from Baylor who already holds the NCAA women's record with 11 dunks and is a three-point play from becoming the Big 12's career scoring leader.
Griner set the NCAA career record for blocked shots, getting the record-tying and record-setting blocks by swatting away a pair of shots by Oklahoma's Aaryn Ellenberg, as the top-ranked Lady Bears won 82-65 Saturday for their 50th consecutive win at home.
"Definitely happy I got that. Now I'm going to try to set it higher," the 6-foot-8 Griner said. "Blocked shots keep the other team from scoring, that's just how I look at it. Blocked shots kind of remind me when I played volleyball, I used to love to spike. ... That's why I like (blocks) the most."
With eight in the game, Griner has 665 career blocks, two more than Louella Tomlinson had for St. Mary's in California (2007-11).
"As good as she is on the offensive end, where she really changes games is on the defensive end," Oklahoma coach Sherri Coale said. "She obviously has the wingspan and the athleticism, but she also has that ornate sense that I think all great shot blockers have knowing when to go get it."
By fouling out for only the second time in her 131 career games, Griner missed a chance to also break the Big 12 scoring record before the Lady Bears (18-1, 8-0 Big 12) play their next two games on the road. Her 2,833 career points are two shy of matching Oklahoma State's Andrea Riley's (2007-10).
Griner finished with 15 points to lead six players in double figures for Baylor, which has won 36 consecutive Big 12 regular-season and tournament games since a loss to Oklahoma in the conference tournament three years ago.
Odyssey Sims had 12 points and 10 assists while Destiny Williams had 11 points and 10 rebounds.
Ellenberg had 33 points for the Sooners (15-4, 5-2). Joanna McFarland had 12 points and 16 rebounds.
Griner got her 663rd career block with just under 13 minutes left. A similar play with 10:25 remaining was Griner's seventh of the game and broke Tomlinson's record.
With 5:14 to go, Griner was called for a foul on another shot by Ellenberg. It was the first time she fouled out since the second game of her freshman season.
"Disappointed I fouled out at the end of the game," Griner said.
That came less than a minute after Griner was called for a charge against McFarland for the second time in the game.
In a 30-second span of the first half, McFarland drew charges against Griner and Jordan Madden and hit a 3-pointer in between.
"It's not like a fear. You've just got to go in and bow up, like if she goes hard at me, I've got to go hard back," McFarland said. "It's a mutual thing."
McFarland's long-range shot pulled the Sooners within 26-21, but they never got closer.
The Sooners made 11 of 26 3-pointers, but were just 9 of 46 inside the arc.
"I'm really proud of our guys, I thought we competed and fought every step of the way, and did some really, really good things and attacked them, and went after them, and shot pretty well from 3," Coale said. "Obviously did not shoot well from 2, but there's a big reason for that. Her number's 42 (Griner)."
Oklahoma won the opening tip and Ellenberg immediately hit a 3-pointer. The Sooners were up 10-8 when Ellenberg hit another 3 from the top left of the key 4 minutes later.
Baylor then scored 14 points in a row over the next 5 minutes and took the lead for good. The spurt ended with consecutive baskets by Brooklyn Pope, who finished with 10 points like Kimetria Hayden and Jordan Madden.
Even after shooting 60 percent from the field (35 of 58) and having six players in double figures against the Big 12's second-place team, there were still things for Baylor coach Kim Mulkey to emphasize to her team.
"You have to evaluate yourself and say if you shot like that and had that many players in double figures, why did you only win by 17?," Mulkey said. "Well then it goes back to two things. One, missed free throws, they make free throws. We missed 14 free throws, that's unacceptable. Then they made a lot of 3's."
Not nearly enough though.
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posted on 2013-01-25??|?by Admin | 39 views
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Source: http://www.employmentng.com/jobs/jobdetails.php?recordID=4368
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Nokia continues to turn its ship around, slowly. The Finnish handset maker -- once the world's largest but hit bad by competition from Android device makers and Apple -- today reported Q4 earnings that showed a marked improvement over last quarter. Revenues were $10.7 billion, on EPS of $0.08, beating street expectations. Analysts were expecting EPS of $0.06 on revenues of $10.55 billion. It is also reporting an operating profit of $585 million.Source: http://feedproxy.google.com/~r/Techcrunch/~3/neKSqVfEPyQ/
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On this week's installment of "Grey's Anatomy," phantom limb syndrome takes over Arizona Robbins (Jessica Capshaw) and the pediatric surgeon -- who had recently (finally) made some progress since losing her leg in a plane crash at the start of Season 9 -- is going to experience a major setback.
Phantom limb syndrome plagues the majority of amputees, "Grey's" star Capshaw explained to HuffPost TV via phone, and it causes painful sensations that an amputated limb is still attached to the body and is moving appropriately with other body parts. "I can only imagine how devastating it would be," Capshaw said. "And it would certainly stop you in your tracks as far as recovery goes. How do you deal with that?"
Below, Capshaw opens up about Arizona's battle this season (which initially "scared [her] off"), being behind this season ("because sometimes it's actually hard to watch"), potential firings at Seattle Grace in the wake of the lawsuit settlement, the debate over just how much gay visibility Callie (Sara Ramirez) and Arizona bring to the TV landscape and much more.
It's been a long season for Arizona. What has it been like for you playing a character who's been in such a dark place?
It's been challenging. It's been really challenging. Shonda [Rhimes, the creator of "Grey's Anatomy"] -- who's like the Oz -- knew way better than I did what the landscape of [Arizona's] journey was going to be. I was scared off by merely the hint of the journey. I just had a baby and I was like, "Wait. Hold on. I'm coming back and I'm going to play this? This is really sad and dark and I want to talk about things that are lovely and light and life-affirming." So I don't know that I was even quite ready for what was about to happen, but, as I tend to do, I said, "Alright. Let's try!" And since we started, it has been dark and it's been challenging and I hope, I pray, authentic.
It's not been pretty. As an actor, I think you get attached to even creating the look of a character and in the beginning, believe you me, I used to look at my makeup artist and say, "Mascara?" [Laughs.] She'd say, "Hmm. I don't know." And I was like, "Yeah, I know. I shouldn't." [Laughs.] It was stripping everything away and you kind of had to lean into it and I did.
Ultimately, it's been a tremendous gift to be given material that is as challenging as this if you feel like you can come out the other end and feel like you did a great job. I'm very proud of the work. But I do have to say, I'm not as current with the episodes as I should be because sometimes it's actually hard to watch for me. And I can't stop talking about the visual effects guys because they're so unbelievable. I mean, they make it look like I have one leg, which also completely flips me out. It's bizarre. And speaking of bizarre, this week's episode really dips into -- Sandra Oh [who plays Cristina] and I were talking about it -- something really cool and totally different and creepy and nightmarish. It's been very interesting to do and ultimately incredibly rewarding.
Yes, in this week's episode, Arizona struggles with phantom limb syndrome. What can you tell viewers about that? Did you do a lot of research?
Yes, I spoke to amputees and we have a wonderful researcher so there was a lot of literature and thankfully, there's a real community. There are places where people who are dealing with this kind of loss can go to to understand the stages, much like grief counselors. If you're lucky enough to be around that kind of resource, you can take advantage of that.
There are many people who go through phantom limb syndrome, which is that you feel excruciating pain where the limb was that is no longer there. So you're on the road to recovery, you're accepting, you're accepting, you're accepting, you're accepting and then all of a sudden, your mind is not communicating correctly with your body and your mind thinks that something's there and it's creating a sensation of pain that your body actually isn't feeling because the limb isn't there. There are a bunch of different therapies and our show represents a couple of them. I can only imagine how devastating it would be. And it would certainly stop you in your tracks as far as recovery goes. How do you deal with that?
That's so upsetting because the last couple episodes, we've seen Arizona really ...
Start to buck up? [Laughs.]
Exactly. Especially in terms of things with Callie. Will the phantom limb be a huge setback for her?
I think the show is definitely not teeing up the story to be one of defeat so I think that ultimately, there's not a closure really, but it's about dealing with this particular syndrome and besting it. She will see an end to it and honestly, it's the road to acceptance and then moving past that because once you can accept that something is gone, you can move on from it. But if you can't accept that it's gone, you're not going anywhere.
At the end of last week's episode, Hunt [Kevin McKidd] learned that the hospital would go bankrupt if they pay the settlement that Arizona, Callie and the other doctors are owed. When will we see the fall out there?
I think it's going to be sooner rather than later. With the arrival of the amazing Constance Zimmer [who's playing Dr. Alana Cahill, a physician?s adviser hired to help Seattle Grace avoid bankruptcy] comes a bottom line. She's kind of the bad news bear. As far as the political climate and the social climate goes right now in our country and probably the world, we're all understanding that there's someone ultimately that comes in and has a bottom line and talks about how there are people who are on teams that aren't efficient and you can get rid of them. So when she comes in, that's her job and it definitely upsets the applecart.
Because of the loss of Arizona's leg, we really haven't seen much else between her and Callie this season that doesn't revolve around that issue. Will there be more interactions with them, maybe as parents and more specifically, as gay parents?
Well, it's hard to work to children. [Laughs.] I mean, I would never want to speak for someone else, but I feel that in playing the character, for sure, you absolutely have to celebrate and understand what your specific life will be and who the character is within the framework of the show. But I feel like I've always approached this character and this couple like we're all just people. I've never felt that we needed to politicize it and I've always leaned away from politicizing it because I think the most important thing is showing relationships and partnerships and love and challenge and making it all about one thing has always been less interesting to me. I think the goal is for us all to be who we are and have that be not only OK, but equal.
I mean, listen, if everything was addressed, the show would be three hours. [Laughs.] We have to trust that the audience will make certain acceptances that [Callie and Arizona] are at home being parents and that will come in and out. But I also think from when I was a fan of the show and it's a show about a hospital and a group of doctors. Of course it's always exciting when their personal lives come into it, but it is a show about doctors. We spend 90 percent of our time telling our stories in scrubs so how can it be about much more?
Does it feel like the fact that Callie and Arizona are not really not viewed as a "gay" couple anymore and are just a couple is a sign of progress?
Yeah. I mean, it's not a big thing. It's interesting. We got into a discussion one time because Derek [Patrick Dempsey] and Meredith [Ellen Pompeo] never kissed inside the hospital because that was when they were at work. And something came up one time when we were blocking a scene and we were thinking we might put in a kiss and then we thought, "Hmm. Does this feel right? We're at work. Do people kiss at work?" And then we were wondering, "Well, is it a straight/gay issue? It doesn't feel like that, but is it?" To be frank, there are people who are fans of the show that do wish there was more of that or less of that. I guess, at the end of the day, we always just end up playing the characters the best we can in the moment.
"Grey's Anatomy" airs Thursdays at 9 p.m. EST on ABC.
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